The plan, called the Inflation Reduction Act, cleared the upper chamber on a 51-50 vote along party lines, with Vice President Kamala Harris providing the tie-breaking vote in the equally divided Senate. Democrats used a fast-track legislative process known as reconciliation to pass the measure in the face of unanimous opposition from Republicans. “It’s been a long, hard and winding road, but finally, finally, we’re here,” Senate Majority Leader Chuck Schumer said in remarks on the Senate floor as members prepared to vote on the final passage. “Today, after more than a year of hard work, the Senate is making history. I am confident that the Inflation Reduction Act will stand as one of the defining legislative achievements of the 21st century.” The vote came after a marathon session that lasted through the night and into Sunday afternoon, with Democrats erupting in applause as members cast their final vote. In a process known as a “vote-a-rama,” Republicans offered a series of amendments that Democrats successfully pushed through nearly 16 hours of debate. GOP senators managed to block a provision that would have capped the price of insulin at $35 a month for those covered by private health care plans. Democrats needed 60 votes to waive reconciliation rules and keep that part of the bill, but it failed 57-43, with seven Republicans joining Democrats in supporting the measure. House Democratic leaders announced last week that the lower house will return from a month-long recess on Friday to take up the legislation, which is expected to pass. Mr. Biden praised Senate Democrats for passing the plan and acknowledged that it required “a lot of compromises.” He called on the Parliament to immediately approve the bill. “Today, Senate Democrats sided with American families and special interests, voting to lower prescription drug costs, health insurance and everyday energy costs and reduce the deficit while making the richest corporations pay after all their share,” the president said. a statement. “I ran for president promising to make government work for working families again, and that’s what this bill does — period.” The package is the culmination of months of negotiations over Mr. Biden’s domestic policy agenda, which at times appeared to be on life support but revived late last month with the surprise announcement of a deal between Schumer and Senator Joe Manchin, of a moderate Democrat from West Virginia. Senator Joe Manchin speaks with his staff on Capitol Hill in Washington on August 6, 2022. Shuran Huang for The Washington Post via Getty Images While the legislation is much more limited than the massive $3.5 trillion proposal Mr. Biden put forward last year, the tailored package had the support of Manchin and Senator Kyrsten Sinema, an Arizona Democrat whose support was vital. But Democrats are praising the plan as their response to rising consumer prices and for investing nearly $400 billion in climate change, the largest ever. The package allows Medicare to negotiate prescription drug prices, a key Democratic priority expected to save hundreds of billions of dollars over the next 10 years. It also extends enhanced health insurance subsidies that were set to expire at the end of the year and imposes a 15 percent minimum tax on most companies that make more than $1 billion each year. The corporate tax provision emerged as a point of contention as senators neared a final vote on Sunday. Seven Democratic senators — Sinema, Jon Ossoff, Raphael Warnock, Catherine Cortez Masto, Maggie Hassan, Mark Kelly and Jacky Rosen — joined Republicans in supporting an amendment filed by GOP Sen. John Thune of South Dakota that exempts certain companies with support of private funds from the minimum corporate tax rate of 15%. This amendment was adopted by a vote of 57 to 43. To boost clean energy, the measure includes tax credits for the purchase of electric vehicles and the construction of solar panels and wind turbines. It also provides rebates for consumers who buy energy-efficient appliances and provides $4 billion for drought relief. Schumer praised the bill as the “boldest climate package” in US history and called it a “game changer” and a “tipping point”. “It’s been a long time,” he said. One piece of the Democrats’ plan on drug pricing — imposing penalties on drugmakers who raised prices above inflation to private insurers — was stripped after a review by Senate Rep. Elizabeth MacDonough. Her approval of the rest of the package, however, cleared the way for the upper house to proceed with consideration of the bill. The Congressional Budget Office estimates the legislation would reduce the deficit by $102 billion over the next 10 years. Republicans, however, argued that the plan would have little impact on inflation and would instead raise taxes while leading to job losses. In an interview on “Face the Nation” on Sunday, Sen. Rick Scott, R-Florida, claimed that the Democrats’ drug pricing plan will hurt seniors, while the tax component will raise taxes on Americans. “Why would you raise the cost of government? We’re raising taxes,” he said.