It happened at the intersection of Bovaird Drive and Sunny Meadow Boulevard, west of Torbram Road, at 1:19 p.m.
Police say two people, a driver and a female passenger, were taken to the hospital.  The driver is hospitalized in critical condition while the passenger is in serious condition.
The other driver was not injured and remained at the scene, according to police.
Roads in the area are closed for the investigation.